1 Self - Association of Calcium Binding Protein , S 100 a 4 and Metastasis

Self-association of calcium-binding protein S100A4 and metastasis.

Elevated levels of the calcium-binding protein S100A4 promote metastasis and in carcinoma cells are associated with reduced survival of cancer patients. S100A4 interacts with target proteins that affect a number of activities associated with metastatic cells. However, it is not known how many of these interactions are required for S100A4-promoted metastasis, thus hampering the design of specifi...

Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy

بررسی نقش آنزیم ژلاتیناز- B در گسترش سلول‌های توموری و فعالیت متاستازی سرطان سینه

Background: Gelatinase B or collagenase type IV is a 92 kDa protein. In case of over-expression of the gene, because of its collagenase activity, it can be involved in metastasis activity of few cancers e.g. bladder, colorectal and gastric carcinoma. Single nucleotide substitution base polymorphism of C to T at -1562 of promoter region can increase gene expression by decreasing transcription in...

Effect of Feeding Mulberry Leaves Supplemented with Calcium Chloride on Biochemical Contents of the Silkworm

Oral Supplementation with 50, 100 and 150 ?g/ml calcium chloride to the fifth stadium larvae of CSR2xCSR4 biovoltine hybrid silkworm, B. mori on fat body glycogen, protein, and total lipids and haemolymph trehalose and protein have been studied. One of the four normal feeds per day was substituted with treated leaves fed to silkworms at fifth instar larvae. The controls were fed with the leaves...

Biological Applications of Isothermal Titration Calorimetry

     Most of the biological phenomena are influenced by intermolecular recognition and interaction. Thus, understanding the thermodynamics of biomacromolecule ligand interaction is a very interesting area in biochemistry and biotechnology. One of the most powerful techniques to obtain precise information about the energetics of (bio) molecules binding to other biological macromolecules is isoth...